Extracellular nanovesicles released from the commensal yeast Malassezia sympodialis are enriched in allergens and interact with cells in human skin
نویسندگان
چکیده
منابع مشابه
Identification of small RNAs in extracellular vesicles from the commensal yeast Malassezia sympodialis
Malassezia is the dominant fungus in the human skin mycobiome and is associated with common skin disorders including atopic eczema (AE)/dermatitis. Recently, it was found that Malassezia sympodialis secretes nanosized exosome-like vesicles, designated MalaEx, that carry allergens and can induce inflammatory cytokine responses. Extracellular vesicles from different cell-types including fungi hav...
متن کاملGenomic Insights into the Atopic Eczema-Associated Skin Commensal Yeast Malassezia sympodialis
UNLABELLED Malassezia commensal yeasts are associated with a number of skin disorders, such as atopic eczema/dermatitis and dandruff, and they also can cause systemic infections. Here we describe the 7.67-Mbp genome of Malassezia sympodialis, a species associated with atopic eczema, and contrast its genome repertoire with that of Malassezia globosa, associated with dandruff, as well as those of...
متن کاملStructural and Functional Studies of Malassezia Sympodialis-derived Allergens
Atopic eczema (AE) is a chronic inflammatory skin disease characterised by pruritic (itchy) skin lesions. The pathogenic mechanisms underlying AE are still unclear, although several factors such as genetic predisposition, a dysfunctional skin barrier, exposure to environmental allergens and skin colonisation with microorganisms appear to be of importance. Malassezia sympodialis is a yeast which...
متن کاملNanovesicles from Malassezia sympodialis and Host Exosomes Induce Cytokine Responses – Novel Mechanisms for Host-Microbe Interactions in Atopic Eczema
BACKGROUND Intercellular communication can occur via the release of membrane vesicles. Exosomes are nanovesicles released from the endosomal compartment of cells. Depending on their cell of origin and their cargo they can exert different immunoregulatory functions. Recently, fungi were found to produce extracellular vesicles that can influence host-microbe interactions. The yeast Malassezia sym...
متن کاملThe frequency of skin allergens in patients with contact dermatitis
Background: Eczema is one of the most widely spread inflammatory skin disorders contact dermatitis is an eczematous dermatitis that is produced as a result of contact with a substance in the environment. The substance can act as an irritant or allergen. Every country has allergen particular to itself. Objective: Determining the frequency of skin allergens in patients with contact dermatitis in ...
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ژورنال
عنوان ژورنال: Scientific Reports
سال: 2018
ISSN: 2045-2322
DOI: 10.1038/s41598-018-27451-9